Publications

Main Content

2021 Publications

  • da Silva AA, Hall JE, Dai X, Wang Z, Salgado MC, do Carmo JM. Chronic Antidiabetic Actions of Leptin: Evidence From Parabiosis Studies for a CNS-Derived Circulating Antidiabetic Factor. Diabetes. 2021 Oct;70(10):2264-2274. doi: 10.2337/db21-0126. Epub 2021 Aug 3.
  • Moore KH, Clemmer JS. Questioning the renoprotective role of L-type calcium channel blockers in chronic kidney disease using physiological modeling.  Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F548-F557. doi: 10.1152/ajprenal.00233.2021. Epub 2021 Sep 6.
  • Rezq S, Huffman AM, Basnet J, Yanes Cardozo LL, Romero DG. Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19. Int J Mol Sci. 2021 Sep 9;22(18):9746. doi: 10.3390/ijms22189746.
  • Chen X, Ashraf S, Ashraf N, Harmancey R.UCP3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin II-Induced Hypertension. J Am Heart Assoc. 2021 Sep 21;10(18):e022556. doi: 10.1161/JAHA.121.022556. Epub 2021 Sep 17.
  • do Carmo JM, da Silva AA, Hall JE. Impact of Mineralocorticoid Receptor and Angiotensin II Type 1 Receptor Antagonism on Blood Pressure Regulation in Obese Zucker Rats: Role of Sex Differences. Am J Hypertens. 2021 Sep 22;34(9):999-1005. doi: 10.1093/ajh/hpaa170.
  • do Carmo JM, Omoto ACM, Dai X, Moak SP, Mega GS, Li X, Wang Z, Mouton AJ, Hall JE, da Silva AA. Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life. Am J Physiol Heart Circ Physiol. 2021 Sep 1;321(3):H485-H495. doi: 10.1152/ajpheart.00176.2021. Epub 2021 Jul 23.
  • Banek CT, Bradshaw JL, Coats LE, Alexander BT, Goulopoulou S. Getting it right: preventing drift in baseline cardiovascular phenotype when using Sprague-Dawley rats. Am J Physiol Heart Circ Physiol. 2021 Sep 1;321(3):H475-H478. doi: 10.1152/ajpheart.00382.2021. Epub 2021 Jul 30.
  • Taylor EB, George EM, Ryan MJ, Garrett MR, Sasser JM. Immunological comparison of pregnant Dahl salt-sensitive and Sprague-Dawley rats commonly used to model characteristics of preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2021 Aug 1;321(2):R125-R138. doi: 10.1152/ajpregu.00298.2020. Epub 2021 Jun 9.
  • Hall JE, Mouton AJ, da Silva AA, Omoto ACM, Wang Z, Li X, do Carmo JM. Obesity, kidney dysfunction, and inflammation: interactions in hypertension. Cardiovasc Res. 2021 Jul 7;117(8):1859-1876. doi: 10.1093/cvr/cvaa336.
  • Rivera-Gonzalez O, Wilson NA, Coats LE, Taylor EB, Speed JS.Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice. Clin Sci (Lond). 2021 Jul 30;135(14):1773-1789. doi: 10.1042/CS20210549.
  • Ashraf S, Ashraf N, Yilmaz G, Harmancey R. Crosstalk between beta-adrenergic and insulin signaling mediates mechanistic target of rapamycin hyperactivation in liver of high-fat diet-fed male mice. Physiol Rep. 2021 Jul;9(13):e14958. doi: 10.14814/phy2.14958.
  • Pandelides Z, Aluru N, Thornton C, Watts HE, Willett KL. Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARγ in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol. Toxicol Sci. 2021 Jul 16;182(1):44-59. doi: 10.1093/toxsci/kfab046.
  • Nemeth Z, Ryan MJ, Granger JP, Drummond HA. Expression of exogenous epithelial sodium channel beta subunit in the mouse middle cerebral artery increases pressure-induced constriction. Am J Hypertens. 2021 Jun 23:hpab098. doi: 10.1093/ajh/hpab098. Online ahead of print.
  • Travis OK, Baik C, Tardo GA, Amaral L, Jackson C, Greer M, Giachelli C, Ibrahim T, Herrock OT, Williams JM, Cornelius DC. Adoptive transfer of placental ischemia-stimulated natural killer cells causes a preeclampsia-like phenotype in pregnant rats. Am J Reprod Immunol. 2021 Jun;85(6):e13386. doi: 10.1111/aji.13386. Epub 2020 Dec 27.PMID: 33315281
  • Cobb MB, Wu W, Attipoe EM, Johnson AC, Garrett MR. Nephron-deficient HSRA rats exhibit renal injury with age but have limited renal damage from streptozotocin-induced hyperglycemia. Am J Physiol. Renal physiology. 2021 June 1;320(6):F1093-F1105. PubMed PMID: 33843272; DOI: 10.1152/ajprenal.00487.2020.
  • Duncan JW, Nemeth Z, Hildebrandt E, Granger JP, Ryan MJ, Drummond HA. Interleukin-17 induces hypertension but does not impair cerebrovascular function in pregnant rats. Pregnancy Hypertens. 2021 June;24:50-57. PubMed PMID: 33677419; PubMed Central PMCID: PMC8159853; DOI: 10.1016/j.preghy.2021.02.009.
  • Fraher D, Mann RJ, Dubuisson MJ, Ellis MK, Yu T, Walder K, Ward AC, Winkler C, Gibert Y. The endocannabinoid system and retinoic acid signaling combine to influence bone growth. Mol Cell Endocrinol. 2021 June 1;529:111267. PubMed PMID: 33839219; PubMed Central PMCID: PMC8127411; DOI: 10.1016/j.mce.2021.111267.
  • Jiao F, Varghese K, Wang S, Liu Y, Yu H, Booz GW, Roman RJ, Liu R, Fan F. Recent Insights Into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases. J Cardiovasc Pharmacol. 2021 June 1;77(6):728-734. PubMed PMID: 34001724; PubMed Central PMCID: PMC8169546; DOI: 10.1097/FJC.0000000000001021.
  • Dungan WC, Garrett MR, Welch BA, Lawson WJ, Himel AR, Dungey A, Vick KD, Grayson BE. Whole genome transcriptome analysis of the stomach resected in human vertical sleeve gastrectomy: cutting more than calories. Physiol Genomics. 2021 May 1;53(5):193-205. PubMed PMID: 33870723; DOI: 10.1152/physiolgenomics.00082.2020.

  • Monroe JD, Basheer F, Gibert Y. Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research. Cells. 2021 May 7;10(5):1132. doi: 10.3390/cells10051132.

  • Travis OK, Tardo GA, Giachelli C, Siddiq S, Nguyen HT, Crosby MT, Johnson T, Brown AK, Williams JM, Cornelius DC. Tumor Necrosis Factor-alpha Blockade Improves Uterine Artery Resistance, Maternal Blood Pressure, and Fetal Growth in Placental Ischemic Rats. Pregnancy Hypertens. 2021 May 14;25:39-47. doi: 10.1016/j.preghy.2021.05.002. Online ahead of print. PMID: 34051437.
  • Mouton AJ, Flynn ER, Moak SP, Aitken NM, Omoto ACM, Li X, da Silva AA, Wang Z, do Carmo JM, Hall JE. Dimethyl fumarate preserves left ventricular infarct integrity following myocardial infarction via modulation of cardiac macrophage and fibroblast oxidative metabolism. J Mol Cell Cardiol. 2021 May 21;158:38-48. PubMed PMID: 34023353; DOI: 10.1016/j.yjmcc.2021.05.008.
  • Palei AC, Martin HL, Wilson BA, Anderson CD, Granger JP, Spradley FT. Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats. Am J Physiol Heart Circ Physiol. 2021 May 1;320(5):H1949-H1958. doi: 10.1152/ajpheart.00724.2019. Epub 2021 Mar 12.
  • Tull MT, Baer MM, Spitzen TL, Lee AA, Vallender EJ, Garrett MR, Anestis MD, Gratz KL. The Roles of Borderline Personality Disorder Symptoms and Dispositional Capability for Suicide in Suicidal Ideation and Suicide Attempts: Examination of the COMT Val158Met Polymorphism. Psychiatry Res. 2021 May 16;302:114011. doi: 10.1016/j.psychres.2021.114011. Online ahead of print.
  • Stec DE, Abraham NG. Pharmacological and Clinical Significance of Heme Oxygenase-1. Antioxidants (Basel). 2021 May 27;10(6):854. doi: 10.3390/antiox10060854.
  • Huffman AM, Rezq S, Basnet J, Yanes Cardozo LL, Romero DG. SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19. Int J Mol Sci. 2021 Apr 25;22(9):4472. doi: 10.3390/ijms22094472.
  • Kamimura D, Cain-Shields LR, Clark D, Oshunbade AA, Ashley KE, Guild CS, Loprinzi PD, Newton R, Blaha MJ, Suzuki T, Butler J, Hall JE, Correa A, Hall ME. Physical Activity, Inflammation, Coronary Artery Calcification, and Incident Coronary Heart Disease in African Americans: Insights From the Jackson Heart Study. Mayo Clin Proc. 2021 Apr;96(4):901-911. doi: 10.1016/j.mayocp.2020.09.042. Epub 2021 Mar 10.
  • Oshunbade AA, Yimer WK, Valle KA, Clark D 3rd, Kamimura D, White WB, DeFilippis AP, Blaha MJ, Benjamin EJ, O'Brien EC, Mentz RJ, Fox ER, O'Mara CS, Butler J, Correa A, Hall ME. Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2021 Apr 6;10(7):e017320. doi: 10.1161/JAHA.120.017320. Epub 2021 Mar 23.
  • Johnson AC, Wu W, Attipoe EM, Sasser JM, Taylor EB, Showmaker KC, Kyle PB, Lindsey ML, Garrett MR. Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury. Hypertension. 2020 Apr;75(4):1012-1024. doi: 10.1161/HYPERTENSIONAHA.119.14338. Epub 2020 Mar 9.PMID: 32148127.
  • Taylor, EB. The complex role of adipokines in obesity, inflammation, and autoimmunity. Clin Sci (Lond). 2021 Mar; 135(6): 731–752.
  • Speed J, Pruett WA, Lirette ST, Cook JJ, Phillips CL, Grayson BE. Cardiovascular Risk Factors Following Vertical Sleeve Gastrectomy in Black Americans Compared to White Americans. Obes Surg. 2021 Mar;31(3):1004-1012. doi: 10.1007/s11695-020-04938-x. Epub 2020 Aug 22.
  • Phillips CL, Welch BA, Garrett MR, Grayson BE. Regional heterogeneity in rat Peyer's patches through whole transcriptome analysis. Exp Biol Med (Maywood). 2021 Mar;246(5):513-522. doi: 10.1177/1535370220973014. Epub 2020 Nov 25.
  • Waller JP, Burke SP, Engel J, Chade AR, Bidwell GL 3rd. A dose-escalating toxicology study of the candidate biologic ELP-VEGF. Sci Rep. 2021 Mar 18;11(1):6216. doi: 10.1038/s41598-021-85693-6.
  • Yang W, Li Q, Duncan JW, Bakrania BA, Bradshaw JL, Granger JP, Rana S, Spradley FT. Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats. Pregnancy Hypertens. 2021 Mar;23:11-17.
  • Liu Y, Zhang H, Wu CY, Yu T, Fang X, Ryu JJ, Zheng B, Chen Z, Roman RJ, Fan F. 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility. Prostaglandins Other Lipid Mediat. 2021 Mar 19;154:106548. doi:10.1016/j.prostaglandins.2021.106548. Online ahead of print.
  • Pruett JE, Torres Fernandez ED, Everman SJ, Vinson RM, Davenport K, Logan MK, Ye SA, Romero DG, Yanes Cardozo LL. Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome. Int J Mol Sci. 2021 Mar 4;22(5):2576. doi: 10.3390/ijms22052576.
  • Coats LE, Bakrania BA, Bamrick-Fernandez DR, Ariatti AM, Rawls AZ, Ojeda NB, Alexander BT. Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat. Am J Physiol Heart Circ Physiol. 2021 Mar 19. doi: 10.1152/ajpheart.00033.2021. Online ahead of print.
  • Mouton AJ, Flynn ER, Moak SP, Li X, da Silva AA, Wang Z, do Carmo JM, Hall ME, Hall JE. Interaction of obesity and hypertension on cardiac metabolic remodeling and survival following myocardial infarction. J Am Heart Assoc. 2021 Mar 16;10(6):e018212. doi: 10.1161/JAHA.120.018212. Epub 2021 Mar 5.
  • Li X, Lu Q, Qiu Y, do Carmo, JM, Wang Z, da Silva AA, Mouton A, Omoto ACM, Hall ME, Li J, Hall JE. Direct cardiac actions of the sodium glucose co-transporter 2 inhibitor empagliflozin improve myocardial oxidative phosphorylation and attenuate pressure-overload heart failure. J Am Heart Assoc. 2021 Mar16;10(6):e018298. doi: 10.1161/JAHA.120.018298. Epub 2021 Mar 13.
  • Liu X, Zhang J, Zeigler AC, Nelson AR, Lindsey ML, Saucerman JJ. Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues. J immunol. 2021 Feb 15:206(4):883-891.doi: 10.4049/jimmunol.1901444. Epub 2021 Jan 6.
  • Maeda KJ, McClung DM, Showmaker, KC, Warrington JP, Ryan MJ, Garrett MR, Sasser JM. Endothelial cell disruption drives increased blood-brain barrier permeability and cerebral edema in the Dahl SS/jr rat model of superimposed preeclampsia. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H535-H548. doi: 10.1152/ajpheart.00383.2020. Epub 2020 Dec 4.
  • McClung DM, Kalusche WJ, Jones KE, Ryan MJ, Taylor EB. Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus. Physiol Rep. 2021 Feb;9(3):e14734.  doi: 10.14814/phy2.14734.
  • Liu Y, Zhang H, Wang S, Guo, Y, Fang X, Zheng B, Gao W, Yu H, Chen Z, Roman RJ, Fan F. Reduced pericyte and tight junction coverage in old diabetic rats are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H549-H562. doi: 10.1152/ajpheart.00726.2020. Epub 2020 Dec 11.
  • Chung WC, Challagundla L, Zhou Y, Li M, Atfi A,  Xu K. Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms. Life Sci Alliance. 2021 Feb; 4(2): e201900503.
  • Lodato MB, Boyette JS, Smilo RA, Jackson CR , Halvorson HM, Kuehn KA. Functional importance and diversity of fungi during standing grass litter decomposition. Oecologia.  2021 Jan 9. doi: 10.1007/s00442-020-04838-y. Online ahead of print.
  • Ishimwe JA, Akinleye AA, Johnson AC, Garrett MR, Sasser, JM. Gestational gut microbial remodeling is impaired in a rat model of preeclampsia superimposed on chronic hypertension. Physiol Genomics. 2021 Jan 25. doi: 10.1152/physiolgenomics.00121.2020. Online ahead of print.
  • Zhang C, Fang X, Zhang H, Gao W, Hsu HJ, Roman RJ, Fan F. Genetic susceptibility of hypertension-induced kidney disease. Physiol Rep. 2021 Jan;9(1):e14688. doi: 10.14814/phy2.14688
  • Fan L. Gao W, Liu Y, Jefferson JR, Fan F, Roman RJ. Knockout of γ-Adducin Promotes N G -Nitro-L-Arginine-Methyl-Ester (L-NAME)-InducedHypertensive Renal Injury. J Pharmacol Exp Ther. 2021 Jan 7;JPET-AR-2020-000408. doi: 10.1124/jpet.120.000408. Online ahead of print.
  • Moore, Kyle H; Murphy, Hayley A; George, Eric M. The Glycocalyx: A Central Regulator of Vascular Function. Am J Physiol Regul Integr Comp Physiol. 2021 Jan 27. doi: 10.1152/ajpregu.00340.2020. Online ahead of print.
  • Keele GR, Prokop JW; He H, Holl K. Littrell J, Deal AW Kim Y, Kyle PB, Attipoe E, Johnson AC, Uhl KL, Sirpilla OL, Jahanbakhsh S, Robinson M, Levy S, Valdar W, Garrett MR, Solberg W, Leah C.  Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model. Sci Rep. 2021 Jan 22;11(1):2071. doi: 10.1038/s41598-021-81550-8.
  • Gava FN, da Silva AA, Dai X, Harmancey R, Ashraf S, Omoto Ana CM, Salgado MC, Moak SP, Li X, Hall JE, do Carmo JM. Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System. JACC Basic  Transl Sci. 2021 Jan 25;6(1):55-70. doi: 10.1016/j.jacbts.2020.11.007. eCollection 2021 Jan.
  • Cunningham Jr MW, Amaral LM, Campbell NE, Cornelius DC, Ibrahim T, Vaka VR, LaMarca B. Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia. Biol Sex Differ. 2021 Jan 06; 12 (1) :4. doi: 10.1186/s13293-020-00345-0.
  • Deer E, Vaka VR, McMaster KM, Wallace K, Cornelius DC, Amaral LM, Cunningham MW, LaMarca B. Vascular endothelial mitochondrial oxidative stress in response to preeclampsia: a role for angiotension II type 1 autoantibodies. Am J Obstet Gynecol MFM. 2021 Jan;3(1):100275. doi: 10.1016/j.ajogmf.2020.100275. Epub 2020 Oct 27.
  • Gao W, Liu Y, Fan L, Zheng B, Jefferson JR, Wang S, Zhang H, Fang X, Nguyen BV, Zhu T, Roman RJ, Fan F. Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology. Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F97-F113. doi: 10.1152/ajprenal.00423.2020. Epub 2020 Dec 14.
  • Ren D, He Z, Fedorova J, Zhang J, Wood E, Zhang X, Kang DE, Li J.  Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion. Redox Biol. 2021 Jan; 38: 101824. Published online 2020 Dec 1. doi: 10.1016/j.redox.2020.101824